Fertility and Reproductive Outcome in Mice Following Trichloroethane (TCE) Exposure

M. A. Al-Griw, S. A. Al-Azreg, S. A. Al-Azreg, E. M. Bennour, S. A. M. El-Mahgiubi, A. R. Al-Attar,N.M. Salama, A.Elnfti


Exposure to trichloroethane (TCE), an industrial solvent, has been shown to be negatively associated with reproductive performance. The present study was performed to assess the effects of TCE exposure on the reproductive performance and outcome in mice during a critical developmental window of later reproductive life. A group of female mice were injected intraperitoneally twice weekly for three weeks with TCE (100 and 400 μg/kg). Mice were followed up for signs of toxicity and death. Changes in uterine tissues have also been investigated by histopathology. The results showed that TCE exposure has reduced the number of F0 fertile females comparing to controls. Moreover, TCE exposure resulted in a decreased pups number and changed sex ratio in the litter of F0 TCEtreated dams. Histopathological examination revealed a TCEinduced uterine toxicity appeared as a severe endometrial hyperplasia with squamous cell metaplasia and adenomyosis. These results indicate that TCE exposure during a critical reproductive developmental window could affect the fertility and interfere with the reproductive outcome in mice.

Keyword: TCE; fertility; reproductive outcome; uterus; mice.

Full Text:

PDF 293-303


  • There are currently no refbacks.

Copyright (c) 2016 American Journal of Life Science Researches

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.