Double First Cousin Marriage and Genetic Disorders in South of IRAN

Pooneh Nikuei, kianoosh Malekzadeh Rahman Mahdizadeh ,Razieh Mahdizadeh, Fatemeh Poordarvishi,Fouzieh Hajizadeh, Foroogh Zahedi

Abstract


Marriage between persons biologically related as second cousins are known as consanguineous. Double first cousins arise when siblings of one family reproduce with siblings of another family. A consanguineous couple especially double cousin couple is at increased risk for both autosomal recessive disorders and several congenital malformations. This study is designed in order to illustrate the prevalence of first double cousin marriage and its outcomes in Hormozgan province in south of IRAN. This is a cross-sectional study. Participants are 68 couples who came to medical genetic counseling center because of first double cousin marriage between 2003 to 2013. In 10 years from 2003-2013 genetic counseling was done for 4800 couples. 2856 couples (59.5%) had consanguineous marriage. 68 couples were double first cousin (1.4%). Double first cousin marriage is high risk for offspring to have genetic disorders. Counseling and giving knowledge and information to couples could encourage them to avoid high risk marriages like double first cousin.

Keywords: Double First Cousin, Marriage, Genetic Disorders


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